What are the three layers of the skin in order from outer to inner?

• A. Dermis, epidermis, hypodermis
• B. Hypodermis, dermis, epidermis
• C. Epidermis, dermis, hypodermis
• D. Epidermis, hypodermis, dermis

Answer: (C)

From the outside in, the skin has three layers. The outermost layer, the epidermis, forms the protective surface barrier and is made mainly of keratinocytes; it continually renews itself and provides shielding against abrasion and pathogens. Directly beneath it is the dermis, a thicker, supportive layer rich in collagen and elastin that gives the skin strength and elasticity. It houses blood vessels, nerves, sweat and oil glands, and hair follicles, which enables sensation, hydration, and temperature regulation. The deepest layer is the hypodermis (subcutaneous tissue), composed mostly of fat and connective tissue that cushions, insulates, and anchors the skin to underlying structures. While some sources treat the hypodermis as separate from the skin proper, this three-layer view lists the order from outer to inner as epidermis, dermis, then hypodermis.